 Clinical
study - 2006
The
latest study conducted on NeOpuntia® showed amazing results.
This study, conducted on more than 60 people, revealed another
facet of NeOpuntia® : beyond its weight management properties,
NeOpuntia® offers further health benefits.
The
study highlighted the positive role of NeOpuntia®
in balancing blood lipid levels (HDL & LDL cholesterol), parameters
which are linked to Syndrome X* diagnosis.... More in
details :
- On day
14, NeOpuntia® tripled the benefits of a well-balanced
diet, decreasing the LDL cholesterol level by 10%, compared
to only 3% obtained with placebo.
- Most
importantly, NeOpuntia® improved the level of "good
cholesterol" (HDL cholesterol level) which is associated
with a reduced cardiovascular risk**.
- And on
day 42, near than 40% of women in the NeOpuntia® group
were diagnosed to be free from Metabolic syndrome
(Syndrome X).
NeOpuntia®,
more than a weight management fiber : a fully qualified health
ingredient for nutraceutical and food applications.
The
seriousness and the relevance
of these results allowed the study to be published in
an international scientific publication :
E.
Linares et al. "The effect of NeOpuntia® on blood
lipid parameters - Risk factors for the Metabolic Syndrome
(Syndrome X)". Advances in Therapy Vol. 24; No.5,
September/October 2007; (1113-1123 ).
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*Syndrome X (Metabolic Syndrome) : the sum of non pathological
disorders (including abdominal obesity) which would constitute
THE cardiovascular risk factor.
**Lipid
Research Program : the lipid research clinics coronary prevention
trial results. JAMA 1984 ; 251 : 351-374. & Circulation 1986
; 74 : 1217-1225.
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TNO in vitro study - 2005
The results
confirm lipophilic properties of NeOpuntia® - if compared
to the previous results obtained with the same TNO model :
associated to an American breakfast intake, NeOpuntia®
absorbs about 23% of total fatty acids compared to a control.
This study
is particularly interesting because fat binding capacity of
NeOpuntia® is confirmed when the ingredient is added to
a complex food formula, like a traditional American breakfast.
Further
research is necessary to optimize the method of incorporation
of NeOpuntia® with the meal. From the knowledge we currently
have, applications in which NeOpuntia® can be mixed directly
with the lipid phase of a food formula, are the one which
might give a successful reduction of lipid absorption.
This
study shows a real potential interest of NeOpuntia® as
a food ingredient. Associated in food formula, NeOpuntia®
could prevent some of the fat metabolism while keeping satisfaction
linked to the taste of fat.
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TNO in vitro comparison study - 2004
NeOpuntia®
has been compared with a branded chitosan.... See the following page
for comparison test.
CERN Pilot clinical study - 2003
BIO
SERAE conducted a Pilot Clinical Study based on NeOpuntia®’s
lipophilic properties. The cactus powder developed by BIO SERAE
was clinically tested on 10 healthy volunteers aged 21 to 50 (5
women & 5 men) to confirm its capacity to attract fat.
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The
results of this double blind study, controlled by placebo, randomized
and crossed on 2 groups suggest that the daily consumption of
NeOpuntia® for one week favours the excretion of fat.
The
study showed that the quantity of fat excreted compared to the
quantity ingested increased on average by 27.4%, when taken NeOpuntia®
compared to placebo.
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Complementary researches : fat soluble vitamins & bile acids
Based on the complementary results obtained thanks to the different
studies BIO SERAE conducted, we now know that :
- NeOpuntia®
does not bind in a selective way to fat-soluble vitamins A
and E either in vitro or in vivo.
- Due
to the effect of its fiber and its method of working, NeOpuntia®
collects some of the bile acids and makes them unavailable for digestion
of lipids by pancreatic lipase.
TNO in vitro study - 2001
The
lipophilic capacity of NeOpuntiaŽ was tested in a dynamic in
vitro model of the gastrointestinal tract. This model very
closely simulates the human digestion conditions of fat. This
study was conducted at TNO Nutrition and Food Research (The
Netherlands).
2 grams of NeOpuntiaŽ were added to a standardized meal consisting
of 20 grams of sunflower oil, which was homogenized with 144g
of skim yogurt. Various fractions were collected from all the
gastro-intestinal compartments and the fatty acid composition
was analyzed.
This study shows that NeOpuntiaŽ absorbs 28,3% of total
fatty acids during the 4-hour experiment time frame.
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